Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis

Excessive cholesterol contributes to the development of cardiovascular diseases. Berberine (BBR) has been reported to regulate cholesterol homeostasis. Here, we found that BBR could ameliorate the hepatic autophagic flux blockade caused by cholesterol overloading. The underlying mechanism included l...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Sun, Haidong, Liu, Qian, Hu, Hai, Jiang, Yisheng, Shao, Wentao, Wang, Qihan, Jiang, Zhaoyan, Gu, Aihua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070517/
https://ncbi.nlm.nih.gov/pubmed/30068904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0890-5
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