Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis

Excessive cholesterol contributes to the development of cardiovascular diseases. Berberine (BBR) has been reported to regulate cholesterol homeostasis. Here, we found that BBR could ameliorate the hepatic autophagic flux blockade caused by cholesterol overloading. The underlying mechanism included l...

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Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Sun, Haidong, Liu, Qian, Hu, Hai, Jiang, Yisheng, Shao, Wentao, Wang, Qihan, Jiang, Zhaoyan, Gu, Aihua
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070517/
https://ncbi.nlm.nih.gov/pubmed/30068904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0890-5
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