Plk1 overexpression induces chromosomal instability and suppresses tumor development

Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene and an attractive cancer target. However, its contribution to tumor development is unclear. Using a new inducible knock-in mouse model we report here that Plk1 overexpression res...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: de Cárcer, Guillermo, Venkateswaran, Sharavan Vishaan, Salgueiro, Lorena, El Bakkali, Aicha, Somogyi, Kalman, Rowald, Konstantina, Montañés, Pablo, Sanclemente, Manuel, Escobar, Beatriz, de Martino, Alba, McGranahan, Nicholas, Malumbres, Marcos, Sotillo, Rocío
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6070485/
https://ncbi.nlm.nih.gov/pubmed/30069007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05429-5
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