Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that simultaneous overexpression of the mitotic checkpoint protein Mad2 with Kras(G12D) or Her2 in mam...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Rowald, Konstantina, Mantovan, Martina, Passos, Joana, Buccitelli, Christopher, Mardin, Balca R., Korbel, Jan O., Jechlinger, Martin, Sotillo, Rocio
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920917/
https://ncbi.nlm.nih.gov/pubmed/27292643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.048
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados