Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

Chromosome instability (CIN) is associated with poor survival and therapeutic outcome in a number of malignancies. Despite this correlation, CIN can also lead to growth disadvantages. Here, we show that simultaneous overexpression of the mitotic checkpoint protein Mad2 with Kras(G12D) or Her2 in mam...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Rowald, Konstantina, Mantovan, Martina, Passos, Joana, Buccitelli, Christopher, Mardin, Balca R., Korbel, Jan O., Jechlinger, Martin, Sotillo, Rocio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920917/
https://ncbi.nlm.nih.gov/pubmed/27292643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.048
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