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Assessment of Substrate-Dependent Ligand Interactions at the Organic Cation Transporter OCT2 Using Six Model Substrates
Organic cation transporter (OCT) 2 mediates the entry step for organic cation secretion by renal proximal tubule cells and is a site of unwanted drug-drug interactions (DDIs). But reliance on decision tree–based predictions of DDIs at OCT2 that depend on IC(50) values can be suspect because they can...
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| Veröffentlicht in: | Mol Pharmacol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6070079/ https://ncbi.nlm.nih.gov/pubmed/29884691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.111443 |
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