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Substrate-Dependent Ligand Inhibition of the Human Organic Cation Transporter OCT2

Organic cation transporter 2 (OCT2) mediates the initial step in renal secretion of organic cations: uptake from the blood, across the basolateral membrane, and into the renal proximal tubule cells. Because of its potential as a target for unwanted drug-drug interactions (DDIs), considerable attenti...

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Autori principali: Belzer, Mathew, Morales, Mark, Jagadish, Bhumasamudram, Mash, Eugene A., Wright, Stephen H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716314/
https://ncbi.nlm.nih.gov/pubmed/23709117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.203257
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