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Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2
OCT2 is the entry step for organic cation (OC) secretion by renal proximal tubules. Although many drugs inhibit OCT2 activity, neither the mechanistic basis of their inhibition nor their transport status is generally known. Using representatives of several structural classes of OCT2-inhibitory ligan...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971011/ https://ncbi.nlm.nih.gov/pubmed/23034939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00486.2012 |
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