UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes

Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7-dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting considerable attention because of their wide spectrum of biologic activities, but their metabolism remains unknown. This study aimed to elucidate th...

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Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Zhu, Lijun, Lu, Linlin, Zeng, Shan, Luo, Feifei, Dai, Peimin, Wu, Peng, Wang, Ying, Liu, Liang, Hu, Ming, Liu, Zhongqiu
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067388/
https://ncbi.nlm.nih.gov/pubmed/25854527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063552
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