UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes

Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7-dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting considerable attention because of their wide spectrum of biologic activities, but their metabolism remains unknown. This study aimed to elucidate th...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Drug Metab Dispos
Главные авторы: Zhu, Lijun, Lu, Linlin, Zeng, Shan, Luo, Feifei, Dai, Peimin, Wu, Peng, Wang, Ying, Liu, Liang, Hu, Ming, Liu, Zhongqiu
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2015
Предметы:
Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067388/
https://ncbi.nlm.nih.gov/pubmed/25854527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.063552
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы