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Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1
SAMHD1 is a dNTP triphosphohydrolase (dNTPase) that impairs retroviral replication in a subset of noncycling immune cells. Here we show that SAMHD1 is a redox-sensitive enzyme and identify three redox-active cysteines within the protein: C341, C350, and C522. The three cysteines reside near one anot...
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| 出版年: | Cell Rep |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6067006/ https://ncbi.nlm.nih.gov/pubmed/30044979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.090 |
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