The role of Twist1 in mutant huntingtin–induced transcriptional alterations and neurotoxicity

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an abnormal expansion of polyglutamine repeats in the huntingtin protein (Htt). Transcriptional dysregulation is an early event in the course of HD progression and is thought to contribute to disease pathogenesis, but how...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Pan, Yanchun, Zhu, Ying, Yang, Wei, Tycksen, Eric, Liu, Shaopeng, Palucki, John, Zhu, Linjian, Sasaki, Yo, Sharma, Mukesh K., Kim, Albert H., Zhang, Bo, Yano, Hiroko
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066321/
https://ncbi.nlm.nih.gov/pubmed/29891550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001211
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