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LRP1 is required for novobiocin-mediated fibronectin turnover

Fibronectin (FN) plays a major role in the stability and organization of the extracellular matrix (ECM). We have previously demonstrated that FN interacts directly with Hsp90, as well as showing that the Hsp90 inhibitor novobiocin results in FN turnover via a receptor mediated process. However, the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Boel, Natasha Marie-Eraine, Hunter, Morgan Campbell, Edkins, Adrienne Lesley
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065439/
https://ncbi.nlm.nih.gov/pubmed/30061663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29531-2
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