Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells

Heat shock protein 90 (Hsp90) has been identified in the extracellular space and has been shown to chaperone a finite number of extracellular proteins involved in cell migration and invasion. We used chemical cross-linking and immunoprecipitation followed by tandem mass spectrometry (MS/MS) to isola...

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Main Authors: Hunter, Morgan C., O’Hagan, Kyle L., Kenyon, Amy, Dhanani, Karim C. H., Prinsloo, Earl, Edkins, Adrienne L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899338/
https://ncbi.nlm.nih.gov/pubmed/24466266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086842
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