Defects in MAP1S-mediated autophagy turnover of fibronectin cause renal fibrosis

Excessive deposition of extracellular matrix proteins in renal tissues causes renal fibrosis and renal function failure. Mammalian cells primarily use the autophagy-lysosome system to degrade misfolded/aggregated proteins and dysfunctional organelles. MAP1S is an autophagy activator and promotes the...

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Detalles Bibliográficos
Publicado en:Aging (Albany NY)
Autores principales: Xu, Guibin, Yue, Fei, Huang, Hai, He, Yongzhong, Li, Xun, Zhao, Haibo, Su, Zhengming, Jiang, Xianhan, Li, Wenjiao, Zou, Jing, Chen, Qi, Liu, Leyuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931848/
https://ncbi.nlm.nih.gov/pubmed/27236336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.100957
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