Superinfection and cure of infected cells as mechanisms for hepatitis C virus adaptation and persistence

RNA viruses exist as a genetically diverse quasispecies with extraordinary ability to adapt to abrupt changes in the host environment. However, the molecular mechanisms that contribute to their rapid adaptation and persistence in vivo are not well studied. Here, we probe hepatitis C virus (HCV) pers...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Ke, Ruian, Li, Hui, Wang, Shuyi, Ding, Wenge, Ribeiro, Ruy M., Giorgi, Elena E., Bhattacharya, Tanmoy, Barnard, Richard J. O., Hahn, Beatrice H., Shaw, George M., Perelson, Alan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6065014/
https://ncbi.nlm.nih.gov/pubmed/29987026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805267115
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