SOCS3 Suppression Promoted the Recruitment of CD11b(+)Gr-1(−)F4/80(−)MHCII(−) Early-Stage Myeloid-Derived Suppressor Cells and Accelerated Interleukin-6-Related Tumor Invasion via Affecting Myeloid Differentiation in Breast Cancer

Interleukin-6 (IL-6) is an important trigger for the expansion and recruitment of myeloid-derived suppressor cells (MDSCs), which are regarded to be major coordinators of the immunosuppressive tumor microenvironment. In this study, we constructed IL-6-knockdown breast cancer mice models to explore t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhang, Wenwen, Jiang, Mengmeng, Chen, Jieying, Zhang, Rui, Ye, Yingnan, Liu, Pengpeng, Yu, Wenwen, Yu, Jinpu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064721/
https://ncbi.nlm.nih.gov/pubmed/30083161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01699
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