Hippo Signaling Pathway Dysregulation in Human Huntington’s Disease Brain and Neuronal Stem Cells

The Hippo signaling pathway is involved in organ size regulation and tumor suppression. Although inhibition of Hippo leads to tumorigenesis, activation of Hippo may play a role in neurodegeneration. Specifically, activation of the upstream regulator, mammalian sterile 20 (STE20)-like kinase 1 (MST1)...

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Udgivet i:Sci Rep
Main Authors: Mueller, Kaly A., Glajch, Kelly E., Huizenga, Megan N., Wilson, Remi A., Granucci, Eric J., Dios, Amanda M., Tousley, Adelaide R., Iuliano, Maria, Weisman, Elizabeth, LaQuaglia, Michael J., DiFiglia, Marian, Kegel-Gleason, Kimberly, Vakili, Khashayar, Sadri-Vakili, Ghazaleh
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063913/
https://ncbi.nlm.nih.gov/pubmed/30054496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29319-4
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