Enhanced bacterial immunity and mammalian genome editing via RNA polymerase-mediated dislodging of Cas9 from double strand DNA breaks

The ability to target the Cas9 nuclease to DNA sequences via Watson-Crick base pairing with a single guide RNA (sgRNA) has provided a dynamic tool for genome editing and an essential component of adaptive immune systems in bacteria. After generating a double strand break n(DSB), Cas9 remains stably...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Clarke, Ryan, Heler, Robert, MacDougall, Matthew S., Yeo, Nan Cher, Chavez, Alejandro, Regan, Maureen, Hanakahi, Leslyn, Church, George M., Marraffini, Luciano A., Merrill, Bradley J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063522/
https://ncbi.nlm.nih.gov/pubmed/29979968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.005
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