HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer

BACKGROUND. A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) missense that increases metabolic flux from extragonadal precursor steroids to DHT synthesis in prostate cancer. Enabling of extragonadal DHT synthesis by HSD3B1(1245C) pr...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Alyamani, Mohammad, Emamekhoo, Hamid, Park, Sunho, Taylor, Jennifer, Almassi, Nima, Upadhyay, Sunil, Tyler, Allison, Berk, Michael P., Hu, Bo, Hwang, Tae Hyun, Figg, William Douglas, Peer, Cody J., Chien, Caly, Koshkin, Vadim S., Mendiratta, Prateek, Grivas, Petros, Rini, Brian, Garcia, Jorge, Auchus, Richard J., Sharifi, Nima
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2018
Onderwerpen:
Clinical Medicine
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063492/
https://ncbi.nlm.nih.gov/pubmed/29939161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98319
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