HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer

BACKGROUND. A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) missense that increases metabolic flux from extragonadal precursor steroids to DHT synthesis in prostate cancer. Enabling of extragonadal DHT synthesis by HSD3B1(1245C) pr...

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Vydáno v:J Clin Invest
Hlavní autoři: Alyamani, Mohammad, Emamekhoo, Hamid, Park, Sunho, Taylor, Jennifer, Almassi, Nima, Upadhyay, Sunil, Tyler, Allison, Berk, Michael P., Hu, Bo, Hwang, Tae Hyun, Figg, William Douglas, Peer, Cody J., Chien, Caly, Koshkin, Vadim S., Mendiratta, Prateek, Grivas, Petros, Rini, Brian, Garcia, Jorge, Auchus, Richard J., Sharifi, Nima
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063492/
https://ncbi.nlm.nih.gov/pubmed/29939161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98319
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