Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes

In type 1 diabetes, cytotoxic CD8(+) T cells with specificity for β cell autoantigens are found in the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells. In contrast, the disease relevance of β cell–reactive CD8(+) T cells that are detectable in the circula...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Yeo, Lorraine, Woodwyk, Alyssa, Sood, Sanjana, Lorenc, Anna, Eichmann, Martin, Pujol-Autonell, Irma, Melchiotti, Rosella, Skowera, Ania, Fidanis, Efthymios, Dolton, Garry M., Tungatt, Katie, Sewell, Andrew K., Heck, Susanne, Saxena, Alka, Beam, Craig A., Peakman, Mark
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063477/
https://ncbi.nlm.nih.gov/pubmed/29851415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120555
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