Circulating β cell‐specific CD8(+) T cells restricted by high‐risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes

In type 1 diabetes (T1D), autoreactive cytotoxic CD8(+) T cells are implicated in the destruction of insulin‐producing β cells. The HLA‐B*3906 and HLA‐A*2402 class I genes confer increased risk and promote early disease onset, suggesting that CD8(+) T cells that recognize peptides presented by these...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Yeo, L., Pujol‐Autonell, I., Baptista, R., Eichmann, M., Kronenberg‐Versteeg, D., Heck, S., Dolton, G., Sewell, A. K., Härkönen, T., Mikk, M.‐L., Toppari, J., Veijola, R., Knip, M., Ilonen, J., Peakman, M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008222/
https://ncbi.nlm.nih.gov/pubmed/31660582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.13391
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados