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Circulating β cell‐specific CD8(+) T cells restricted by high‐risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes
In type 1 diabetes (T1D), autoreactive cytotoxic CD8(+) T cells are implicated in the destruction of insulin‐producing β cells. The HLA‐B*3906 and HLA‐A*2402 class I genes confer increased risk and promote early disease onset, suggesting that CD8(+) T cells that recognize peptides presented by these...
Zapisane w:
| Wydane w: | Clin Exp Immunol |
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| Główni autorzy: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
John Wiley and Sons Inc.
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008222/ https://ncbi.nlm.nih.gov/pubmed/31660582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.13391 |
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