A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells

CD8 T cells specific for islet autoantigens are major effectors of β cell damage in type 1 diabetes, and measurement of their number and functional characteristics in blood represent potentially important disease biomarkers. CD8 T cell reactivity against glutamic acid decarboxylase 65 (GAD65) in HLA...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Knight, R R, Dolton, G, Kronenberg-Versteeg, D, Eichmann, M, Zhao, M, Huang, G C, Beck, K, Cole, D K, Sewell, A K, Skowera, A, Peakman, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260902/
https://ncbi.nlm.nih.gov/pubmed/25112375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12436
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