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Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias

Reports suggesting a pathogenic role of autoantibodies directed against glutamic acid decarboxylase 65 (GAD65Abs) in cerebellar ataxias (CAs) are reviewed, and debatable issues such as internalization of antibodies by neurons and roles of epitopes are discussed. GAD65 is one of two enzymes that cata...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Mitoma, Hiroshi, Manto, Mario, Hampe, Christiane S.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5366212/
https://ncbi.nlm.nih.gov/pubmed/28386570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/2913297
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