Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo

PDGF-CC is a member of the platelet-derived growth factor (PDGF) family that stimulates PDGFRα phosphorylation and thereby activates intracellular signalling events essential for development but also in cancer, fibrosis and neuropathologies involving blood-brain barrier (BBB) disruption. In order to...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Li, Hong, Zeitelhofer, Manuel, Nilsson, Ingrid, Liu, Xicong, Allan, Laura, Gloria, Benjamin, Perani, Angelo, Murone, Carmel, Catimel, Bruno, Neville, A. Munro, Scott, Fiona E., Scott, Andrew M., Eriksson, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063412/
https://ncbi.nlm.nih.gov/pubmed/30052660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201089
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