Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC(hum) mice

Platelet-derived growth factor CC (PDGF-CC) is important during foetal development but also in pathogenesis of neurologic diseases, cancer and fibrosis. We have previously demonstrated that blocking the PDGF-CC/PDGF receptor alpha (PDGFRα) axis resulted in reduction of stroke volume and cerebrovascu...

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Vydáno v:PLoS One
Hlavní autoři: Zeitelhofer, Manuel, Li, Hong, Adzemovic, Milena Z., Nilsson, Ingrid, Muhl, Lars, Scott, Andrew M., Eriksson, Ulf
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6051635/
https://ncbi.nlm.nih.gov/pubmed/30021009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200649
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