Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with unknown origins. Neurodegeneration in ALS mouse models occurs together with signs of disrupted blood–spinal cord barrier (BSCB) and regressed capillary network, but the molecular pathways contributing to these vascular pat...

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Pubblicato in:Acta Neuropathol
Autori principali: Lewandowski, Sebastian A., Nilsson, Ingrid, Fredriksson, Linda, Lönnerberg, Peter, Muhl, Lars, Zeitelhofer, Manuel, Adzemovic, Milena Z., Nichterwitz, Susanne, Lawrence, Daniel A., Hedlund, Eva, Eriksson, Ulf
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839168/
https://ncbi.nlm.nih.gov/pubmed/26687981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1520-2
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