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Analysis of Genetic Variation Indicates DNA Shape Involvement in Purifying Selection

Noncoding DNA sequences, which play various roles in gene expression and regulation, are under evolutionary pressure. Gene regulation requires specific protein–DNA binding events, and our previous studies showed that both DNA sequence and shape readout are employed by transcription factors (TFs) to...

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Bibliografiske detaljer
Udgivet i:Mol Biol Evol
Main Authors: Wang, Xiaofei, Zhou, Tianyin, Wunderlich, Zeba, Maurano, Matthew T, DePace, Angela H, Nuzhdin, Sergey V, Rohs, Remo
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063282/
https://ncbi.nlm.nih.gov/pubmed/29850830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msy099
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