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Analysis of Genetic Variation Indicates DNA Shape Involvement in Purifying Selection

Noncoding DNA sequences, which play various roles in gene expression and regulation, are under evolutionary pressure. Gene regulation requires specific protein–DNA binding events, and our previous studies showed that both DNA sequence and shape readout are employed by transcription factors (TFs) to...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Wang, Xiaofei, Zhou, Tianyin, Wunderlich, Zeba, Maurano, Matthew T, DePace, Angela H, Nuzhdin, Sergey V, Rohs, Remo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063282/
https://ncbi.nlm.nih.gov/pubmed/29850830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msy099
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