A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

BACKGROUND: Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic opioid use can cause tolerance and addiction. Recent studies have demonstrated functional interactions between chemokine and opio...

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發表在:Arthritis Res Ther
Main Authors: Dutta, Raini, Lunzer, Mary M., Auger, Jennifer L., Akgün, Eyup, Portoghese, Philip S., Binstadt, Bryce A.
格式: Artigo
語言:Inglês
出版: BioMed Central 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062996/
https://ncbi.nlm.nih.gov/pubmed/30053832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1661-5
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