Identification of an I(Na)-dependent and I(to)-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, yet its ionic mechanisms remain unclear due to a lack of cellular models. Here, we used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a BrS patient (BrS1) to evaluate the...

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Publicado no:Sci Rep
Main Authors: Ma, Dongrui, Liu, Zhenfeng, Loh, Li Jun, Zhao, Yongxing, Li, Guang, Liew, Reginald, Islam, Omedul, Wu, Jianjun, Chung, Ying Ying, Teo, Wee Siong, Ching, Chi Keong, Tan, Boon Yew, Chong, Daniel, Ho, Kah Leng, Lim, Paul, Yong, Rita Yu Yin, Panama, Brian K., Kaplan, Aaron D., Bett, Glenna C. L., Ware, James, Bezzina, Connie R., Verkerk, Arie O., Cook, Stuart A., Rasmusson, Randall L., Wei, Heming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062539/
https://ncbi.nlm.nih.gov/pubmed/30050137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29574-5
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