L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes

Aconitine (ACO) is well-known for causing lethal ventricular tachyarrhythmias. While cardiac Na(+) channel opening during repolarization has long been documented in animal cardiac myocytes, the cellular effects and mechanism of ACO in human remain unexplored. This study aimed to assess the proarrhyt...

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Опубликовано в: :PLoS One
Главные авторы: Wu, Jianjun, Wang, Xiangchong, Chung, Ying Ying, Koh, Cai Hong, Liu, Zhenfeng, Guo, Huicai, Yuan, Qiang, Wang, Chuan, Su, Suwen, Wei, Heming
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215924/
https://ncbi.nlm.nih.gov/pubmed/28056022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168435
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