Identification of an I(Na)-dependent and I(to)-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient

Brugada syndrome (BrS) is an inherited cardiac arrhythmia commonly associated with SCN5A mutations, yet its ionic mechanisms remain unclear due to a lack of cellular models. Here, we used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from a BrS patient (BrS1) to evaluate the...

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Vydáno v:Sci Rep
Hlavní autoři: Ma, Dongrui, Liu, Zhenfeng, Loh, Li Jun, Zhao, Yongxing, Li, Guang, Liew, Reginald, Islam, Omedul, Wu, Jianjun, Chung, Ying Ying, Teo, Wee Siong, Ching, Chi Keong, Tan, Boon Yew, Chong, Daniel, Ho, Kah Leng, Lim, Paul, Yong, Rita Yu Yin, Panama, Brian K., Kaplan, Aaron D., Bett, Glenna C. L., Ware, James, Bezzina, Connie R., Verkerk, Arie O., Cook, Stuart A., Rasmusson, Randall L., Wei, Heming
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062539/
https://ncbi.nlm.nih.gov/pubmed/30050137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29574-5
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