Characterization of a novel KCNQ1 mutation for type 1 long QT syndrome and assessment of the therapeutic potential of a novel IKs activator using patient-specific induced pluripotent stem cell-derived cardiomyocytes

INTRODUCTION: Type 1 long QT syndrome (LQT1) is a common type of cardiac channelopathy associated with loss-of-function mutations of KCNQ1. Currently there is a lack of drugs that target the defected slowly activating delayed rectifier potassium channel (IKs). With LQT1 patient-specific human induce...

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Publicado no:Stem Cell Res Ther
Main Authors: Ma, Dongrui, Wei, Heming, Lu, Jun, Huang, Dou, Liu, Zhenfeng, Loh, Li Jun, Islam, Omedul, Liew, Reginald, Shim, Winston, Cook, Stuart A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396080/
https://ncbi.nlm.nih.gov/pubmed/25889101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-015-0027-z
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