In silico prediction of hERG potassium channel blockage by chemical category approaches

The human ether-a-go-go related gene (hERG) plays an important role in cardiac action potential. It encodes an ion channel protein named Kv11.1, which is related to long QT syndrome and may cause avoidable sudden cardiac death. Therefore, it is important to assess the hERG channel blockage of lead c...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Toxicol Res (Camb)
Main Authors: Zhang, Chen, Zhou, Yuan, Gu, Shikai, Wu, Zengrui, Wu, Wenjie, Liu, Changming, Wang, Kaidong, Liu, Guixia, Li, Weihua, Lee, Philip W., Tang, Yun
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6062199/
https://ncbi.nlm.nih.gov/pubmed/30090371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5tx00294j
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