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Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators

A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR). Studies with the model CAR activator phenobarbital (PB) and its sodium salt (sodium ph...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Toxicol Res (Camb)
1. Verfasser: Lake, Brian G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060665/
https://ncbi.nlm.nih.gov/pubmed/30090615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8tx00008e
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