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Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR). Studies with the model CAR activator phenobarbital (PB) and its sodium salt (sodium ph...
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| Publié dans: | Toxicol Res (Camb) |
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| Auteur principal: | |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Royal Society of Chemistry
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6060665/ https://ncbi.nlm.nih.gov/pubmed/30090615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8tx00008e |
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