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Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation

The pregnane X receptor (PXR/SXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are nuclear receptors (NRs) involved in the regulation of many genes including cytochrome P450 enzymes (CYPs) and transporters important in metabolism and uptake of both endogenous substrates and xenobiotics....

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Pinne, Marija, Ponce, Elsa, Raucy, Judy L.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5061317/
https://ncbi.nlm.nih.gov/pubmed/27732639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164642
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