Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

CRISPR-Cas systems are bacterial anti-viral systems, and bacterial viruses (bacteriophages, phages) can carry anti-CRISPR (Acr) proteins to evade that immunity. Acrs can also fine-tune the activity of CRISPR-based genome-editing tools. While Acrs are prevalent in phages capable of lying dormant in a...

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Pubblicato in:Nat Commun
Autori principali: Hynes, Alexander P., Rousseau, Geneviève M., Agudelo, Daniel, Goulet, Adeline, Amigues, Beatrice, Loehr, Jeremy, Romero, Dennis A., Fremaux, Christophe, Horvath, Philippe, Doyon, Yannick, Cambillau, Christian, Moineau, Sylvain
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6060171/
https://ncbi.nlm.nih.gov/pubmed/30046034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05092-w
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