Catalytic activation of β-arrestin by GPCRs

β-arrestins are critical regulator and transducer proteins for G protein-coupled receptors (GPCRs). Cellular β-arrestin function is presently thought to require stable and stoichiometric GPCR/β-arrestin scaffold complex formation driven by the phosphorylated GPCR tail. We demonstrate a distinct and...

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Udgivet i:Nature
Main Authors: Eichel, Kelsie, Jullié, Damien, Barsi-Rhyne, Benjamin, Latorraca, Naomi R., Masureel, Matthieu, Sibarita, Jean-Baptiste, Dror, Ron O., von Zastrow, Mark
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058965/
https://ncbi.nlm.nih.gov/pubmed/29720660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0079-1
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