A novel regimen for relapsed/refractory adult acute myeloid leukemia using a KMT2A partial tandem duplication targeted therapy: results of phase 1 study NCI 8485

KMT2A partial tandem duplication occurs in approximately 5–10% of patients with acute myeloid leukemia and is associated with adverse prognosis. KMT2A wild type is epigenetically silenced in KMT2A partial tandem duplication; re-expression can be induced with DNA methyltransferase and/or histone deac...

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Publicado no:Haematologica
Main Authors: Mims, Alice S., Mishra, Anjali, Orwick, Shelley, Blachly, James, Klisovic, Rebecca B., Garzon, Ramiro, Walker, Alison R., Devine, Steven M., Walsh, Katherine J., Vasu, Sumithira, Whitman, Susan, Marcucci, Guido, Jones, Daniel, Heerema, Nyla A., Lozanski, Gerard, Caligiuri, Michael A., Bloomfield, Clara D., Byrd, John C., Piekarz, Richard, Grever, Michael R., Blum, William
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058798/
https://ncbi.nlm.nih.gov/pubmed/29567781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.186890
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