Preclinical activity and a pilot phase I study of pacritinib, an oral JAK2/FLT3 inhibitor, and chemotherapy in FLT3-ITD-positive AML

Activating FLT3 internal tandem duplication (FLT3-ITD) mutations in acute myeloid leukemia (AML) associate with inferior outcomes. We determined that pacritinib, a JAK2/FLT3 inhibitor, has in vitro activity against FLT3-ITD and tyrosine kinase domain (TKD) mutations. Therefore, we conducted a phase...

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Veröffentlicht in:Invest New Drugs
Hauptverfasser: Jeon, Jae Yoon, Zhao, Qiuhong, Buelow, Daelynn R., Phelps, Mitch, Walker, Alison R., Mims, Alice S., Vasu, Sumithira, Behbehani, Gregory, Blachly, James, Blum, William, Klisovic, Rebecca B., Byrd, John C., Garzon, Ramiro, Baker, Sharyn D., Bhatnagar, Bhavana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858927/
https://ncbi.nlm.nih.gov/pubmed/31102119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-019-00786-4
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