BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells

Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1...

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Bibliografiset tiedot
Julkaisussa:Haematologica
Päätekijät: Wroblewski, Mark, Scheller-Wendorff, Marina, Udonta, Florian, Bauer, Raimund, Schlichting, Jara, Zhao, Lin, Ben Batalla, Isabel, Gensch, Victoria, Päsler, Sarina, Wu, Lei, Wanior, Marek, Taipaleenmäki, Hanna, Bolamperti, Simona, Najafova, Zeynab, Pantel, Klaus, Bokemeyer, Carsten, Qi, Jun, Hesse, Eric, Knapp, Stefan, Johnsen, Steven, Loges, Sonja
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Ferrata Storti Foundation 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058788/
https://ncbi.nlm.nih.gov/pubmed/29567778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.181354
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