BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells

Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1...

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Publicado en:Haematologica
Main Authors: Wroblewski, Mark, Scheller-Wendorff, Marina, Udonta, Florian, Bauer, Raimund, Schlichting, Jara, Zhao, Lin, Ben Batalla, Isabel, Gensch, Victoria, Päsler, Sarina, Wu, Lei, Wanior, Marek, Taipaleenmäki, Hanna, Bolamperti, Simona, Najafova, Zeynab, Pantel, Klaus, Bokemeyer, Carsten, Qi, Jun, Hesse, Eric, Knapp, Stefan, Johnsen, Steven, Loges, Sonja
Formato: Artigo
Idioma:Inglês
Publicado: Ferrata Storti Foundation 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058788/
https://ncbi.nlm.nih.gov/pubmed/29567778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.181354
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