Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model

Intravenous (IV) topotecan is approved for the treatment of various malignancies including lung cancer but its clinical use is greatly undermined by severe hematopoietic toxicity. We hypothesized that inhalation delivery of topotecan would increase local exposure and efficacy against lung cancer whi...

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Foilsithe in:Drug Deliv
Main Authors: Kuehl, Philip J., Grimes, Marcie J., Dubose, Devon, Burke, Michael, Revelli, David A., Gigliotti, Andrew P., Belinsky, Steven A., Tessema, Mathewos
Formáid: Artigo
Teanga:Inglês
Foilsithe: Taylor & Francis 2018
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058531/
https://ncbi.nlm.nih.gov/pubmed/29779406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2018.1469688
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