Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts

Achieving effective treatment outcomes for patients with glioblastoma (GBM) has been impeded by many obstacles, including the pharmacokinetic limitations of antitumor agents, such as topotecan (TPT). Here, we demonstrate that intravenous administration of a novel nanoliposomal formulation of TPT (nL...

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Main Authors: Serwer, Laura P., Noble, Charles O., Michaud, Karine, Drummond, Daryl C., Kirpotin, Dmitri B., Ozawa, Tomoko, Prados, Michael D., Park, John W., James, C. David
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223095/
https://ncbi.nlm.nih.gov/pubmed/21954443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor139
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