Inhalation delivery dramatically improves the efficacy of topotecan for the treatment of local and distant lung cancer

Topotecan is potent anti-cancer drug approved for various malignancies but hematopoietic toxicities undermine its wider application and use of its most effective dose. This study aims to improve these limitations through inhalation-delivery. The pharmacokinetics, efficacy, and toxicity of 2–5 times...

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Udgivet i:Drug Deliv
Main Authors: Kuehl, Philip J., Yingling, Christin M., Dubose, Devon, Burke, Michael, Revelli, David A., Chen, Wenshu, Dye, Wendy W., Belinsky, Steven A., Tessema, Mathewos
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8079036/
https://ncbi.nlm.nih.gov/pubmed/33860729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2021.1912209
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