Cytosolic Delivery of Multidomain Cargos by the N Terminus of Pasteurella multocida Toxin

The zoonotic pathogen Pasteurella multocida produces a 146-kDa modular toxin (PMT) that enters host cells and manipulates intracellular signaling through action on its Gα protein targets. The N terminus of PMT (PMT-N) mediates cellular uptake through receptor-mediated endocytosis, followed by the de...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Clemons, Nathan C., Bannai, Yuka, Haywood, Elizabeth E., Xu, Yiting, Buschbach, James D., Ho, Mengfei, Wilson, Brenda A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056849/
https://ncbi.nlm.nih.gov/pubmed/29784857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00248-18
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