A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

Endocrine fibroblast growth factors (FGFs) require Klotho transmembrane proteins as necessary co-receptors to activate FGF receptor (FGFR) signaling. In particular, FGF19 and FGF21 function through β-Klotho to regulate glucose and lipid metabolism. Recent research has focused on elucidating how thes...

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Udgivet i:Sci Rep
Main Authors: Shi, Sally Yu, Lu, Ya-Wen, Richardson, Jason, Min, Xiaoshan, Weiszmann, Jennifer, Richards, William G., Wang, Zhulun, Zhang, Zhongqi, Zhang, Jun, Li, Yang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056499/
https://ncbi.nlm.nih.gov/pubmed/30038432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29396-5
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